Hi oscarcleemann,
Welcome to Microsoft Community.
I'm Hahn and I'm here to help you with your concern.
I'm sorry to hear that you're experiencing issues with the Print Screen function on your Windows 10 computer. Based on the information you've provided, it seems that the issue is not related to your keyboard or any other software running in the background.
Here are some suggestions for troubleshooting and fixing the print screen key randomly stopping to work on your computer:
1. Clear Windows’ clipboard. Press Windows + V and select Clear all to delete all of the current saved clipboard data.
2. Turn off Sticky Keys. This accessibility setting can shift the function of certain Windows keyboard shortcuts. In Windows 10: Settings > Ease of Access > Keyboard. Scroll to Sticky Keys, and toggle it off.
3. System File Checker: Run the System File Checker (SFC) tool to scan and repair corrupted or missing system files. Use the System File Checker tool to repair missing or corrupted system files - Microsoft Support
4. Create a New User Profile: Create a new user profile and see if the Print Screen key works as expected in the new profile. This can help determine if the issue is specific to your user profile. Create a local user or administrator account in Windows - Microsoft Support
5. Clean Boot: Perform a clean boot of your Windows system to start with a minimal set of startup programs and services. This can help identify if a third-party application is causing the issue. How to perform a clean boot in Windows - Microsoft Support
Hopefully these results will help you resolve your print screen issue. If none of these methods work, then the Print Screen key randomly stopping working on your computer may be a long-standing Windows bug.
Microsoft attaches great importance to user experience, you can submit your ideas and suggestions through the Feedback Hub, and the development team will regularly review submissions for ideas or fixes.
Send feedback to Microsoft with the Feedback Hub app - Microsoft Support
Please share the feedback link here after submitting as it will allow others on the forum to vote for your submission, including me. More votes will lead to more visibility and higher priority to the development team.
I hope this helps. If there is anything not clear, please do not hesitate to let me know.
Your Sincerely
Hahn - MSFT | Microsoft Community Support Specialist