Article from June 16th on RPG mechanics (some spoilers).

First off here's the Newsarama article. The spoiler (IM GOING TO PLACE NON SPOILER INFO LATER IN POST SO DONT CLICK IF YOU DONT WANT TO READ THE SPOILER) in the article wont be that big to you if you have either a) read the retribution book (it makes sense logically after what happens in that book) or b) listened REALLY closely to the E3 demo that had Shepard helping Mordin and Wrex with that fertile Krogan female. And you could also scroll down the ME3 forum thread list here and find it too.....

Those that haven't done any of thsoe and don't want to know the spoiler read on.

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RPG Elements
The RPG elements that many felt were discarded in ME2 have made their return. There will be work stations placed throughout the game, where Shepard can place a weapon and add any new attachments they have found or bought throughout the game. This gives the player more of a chance to customize each weapon to their personal fighting style. The sheer amount of customization we saw, from weapon elements that will change rate of fire to damage to more stealthy styles was astounding; and this was just from one workbench in one small portion of the game.

In addition to weapons, the abilities your character possesses are much more customizable in ME3 than in ME2. You will start with a "powered-up" Shepard, especially when importing your character from Mass Effect 2, though the exact details of that have not yet been revealed. Long-time fans will recognize most of the abilities, but they will be able to use them and upgrade them in ways they never have before. Passive abilities, like Combat Mastery has several different subcategories under it, like Damage, Recharge Speed, Influence & Duration, Headshots, Weapon Mastery, Influence & Damage, Influence & Dilation. In other words, you won't just add a point to "Operative." Instead, you'll get to choose exactly where that point gets spent, and what boost it gives your Shepard.

Gameplay/Combat
Another important upgrade made in ME3 gameplay wise, is how Shepard moves. The cover system is back, but now you can do so much more than just crouch and vault. Shepard can jump, climb, move seamlessly from cover to cover, and even take over enemy heavy mechs, like the Cerberus Atlas shown in the demo. In the demo, the Soldier, one of the more clunky classes of ME2, moved with practically the grace of a ballerina. Light blue arrows direct the player in the cover system, letting you decide whether you want to roll around a pillar or jump over a cargo box. If you consider yourself a stealth player, these smoother controls should really help with your style of gameplay.

Although you have all these upgrades to your abilities, weapons, and movements, the game will certainly not be a cakewalk. Enemies in Mass Effect 3 have been upgraded as well. For example, enemy tactics that you typically find in a FPS, like ranged enemies pinning you down while a shielded enemy slowly crawls in to attack you, will be seen in this game. Because of this, squad tactics are more important than ever. You can use your squad members to pull the shield from one enemy while you take on the ranged opponent. For Xbox users, this is where the Kinect voice controls in ME3 will come in handy. For the unintiated, on the Xbox 360, you’ll be able to simply tell your squadmates what you’d like them to do. “Liara, move up.” “Garrus, concussive shot.” By giving those verbal commands through the Kinect microphone, you’ll see your squadmates carry out the orders while you concentrate on fighting your own battle.

Squadmates(very minor spoiler, nothing that is plot destroying or a twist of anykind)
Speaking of squad members, from the demos it would seem that players should not expect every NPC they team up with to be on the Normandy for the game’s entirety. During the closed-door demo, Shepard and Anderson are trying to escape Earth in what seems is the start of the Reaper invasion. Once they reach the Normandy, however, Anderson proclaims that he is staying behind to help others escape (but not before throwing Shepard her dog tags and saying she should consider herself reinstated in the Alliance Military). Both Legion and Mordin made cameos as well. Mordin was helping Shepard retrieve a fertile Krogan female and Legion was seen driving a vehicle while Shepard attacked a chasing Reaper. Casey Hudson, the executive producer of the franchise, has said in the past that almost all major characters will make an appearance. It would seem that these cameos and temporary squad mates is how BioWare is going to make that happen.

SPOLER NOTE: If you are wanting to read teh article itself (I inluded almost everything here minus a youtube vid of the gameplay trailer) and don't want to read said spoiler dont read beyond the paragraph I just quoted nor the first line (its italicized) in the article either.

Interview Vid with David Silverman(Bioware employee)
vid link

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So for those that are still doubting RPG mechanics and customization of abilities there you go.

Also in the interview vid, at 3:10 is it just me or is that Vulcan from the newest Star Trek movie?