I'm not sure if this tip is still useful for Win7, but I still use it on my machine, I guess it's hard to break old habits, and since I have an *OLD* machine, I figure it still probably applies.
Instead of disabling or letting Windows manage my Swap file, I make the file size the same for both Min and Max size. I believe the rule used to be 4x whatever your physical RAM is, but that was before we had a huge amount of RAM. Mine is set to 4GB,
because I believe that's the max you can set it at ... at least the max for each individual drive, and even though I have 2 drives, I'm just leaving it at 4GB. If you are running a laptop and have a "recovery" drive from the laptop manufacturer, that's a
good place to stick the Swap file, if there's room.
And yes, I do typically turn off indexing, but again, that's likely because I have such an old system. I know when the indexing feature first came out (I forget exactly what it was called), there was a broad warning on the internet that it would cause
your system to slow down, even if you're using it, even though it was designed to only operate when the system was idle.
One other tip, that I believe would apply to Win7 ... since you have such a huge amount of RAM, you should check your Hibernate setting. If you are running a desktop, it is likely not necessary to even utilize this feature. I am trying to find it on
my system, and not sure if they removed it, or just removed it for desktops, but if I remember, it will save everything in your system memory to a file, if your pc loses power, which is handy for laptops, but I think it's a waste for desktops.