if you have room for it download to your hard drive it will take care of a lot of the clitches and freezing issues,its not so bad with alot of the updates that came out for it.one other thing save,save,save.
I think it depends on the savefile size. At least in my case the freezes & so forth don't seem to crop up until the savefile size is over 4 or 5MB. I did 1 ending, & saw no increase of the glitches per se. Save often & have multiple saves. I can say
for my own game(s) I have 2 primary saves. The first is for when I gain a new level; & the other is my "every little thing" save, where I save after I find a new location, get a new item, get or complete a quest & so on.
I have yet to experience "bad glitching". Ive noticed low framerate after I play for long hours on end and an occasional rock I will get stuck on which I have to revert to a save from a few minutes prior. Nothing that really bugged me though.