Yes just like DeadMoney there are 2 different ending with a different achievement for each other than that all achievement are "Achievable" with one playthrough. Which you could just do what a ihave been doing and making 2 saves and just using the ending
i like better.
It does warn you when you are at the point of no return for a certain ending path. If you did want to just get all your points you could just make a save there and reload it after you finish one ending.
I played both endings .... I prefered to Kill the guy mainly for the XP and items.. even though I have a god save with items and stuff.... But it's no bother to spend an extra hour at max just for 40GP ..