Did you use the INSTALL TO DISC feature or are you simply just running it from the DISC? I did the ITD and I have no read issues. I would recommend if you have the hdd space you ITD and see if it still happens.
I have the same issue, and tried everything, installing, clearing cache, deleting and re-installing title updates, removing any external hard drives, removing and re-installing internal hard drive, on third copy of the game and still nothing. XBox is less
than a year out the factory and yet I have this issue. My friends have xbox's several years older than mine and it works fine..... Xbox support is no help!