About FRICKIN TIME!!! I think it may also be Las Venatauras (GTA equivalent). There has been a lot of recent pics by R* employees about San Francisco, Las Vegas, and Los Angeles. So I'm hoping it's a redone San Andreas. It is still possible to do this; just
look at LA NOIRE's technique: use more than one disc. I've got the 250 GB hard drive, so bring it on! Also, one clue that this might be is the new 320 (?) GB hard drive coming out for Xbox 360s.
@GERMINATOR, you will probably hate me then because I (and a lot of others) are FOR SAN ANDREAS. Not only that, but recent clues AND the new logo point to Las Ventauras, Los Santos, San Andreas, or Washington D.C.