-Upgrade your Eve & Health bars at least twice. If you want to play a little bit safer, then upgrade your eve 3 times and your health 4 times. More than that is a waste of adam.
-Save often. Every time you enter a new area, before fighting a big daddy, after fighting a big daddy. You get the idea
-Try to hack everything: Health station, Turrets, Safes, Stores, and Cameras.
-Try to upgrade every weapon.
-Use the Research camera on every single enemy type, especially on the Big Daddies and the Houdini splicers.
-Keep in mind that you cannot loot enemies if you destroy them while they are frozen.
-Keep in mind that you cannot research friendly turrets, bots, or surveillance cameras.
-Keep in mind that the improved plasmids are cheaper on the next level.
-Keep in mind that there are 5 missable audio diaries. 2 are located in the Kashmir Restaurant (beginning of the game) and 3 in Hephaestus (before you meet Andrew Ryan)
Big Daddies Strategies
The layout I recommend is:
Plasmids: Telekinesis, Winter Blast 3, Electro Bolt 2, Insect Swarm 3, Hypnotize Big Daddy 2, Incinerate! 3
Physical: Hacker's Delight 3, Medical Expert 3, Booze Hound, Eve Saver, Eve link 2, SportBoost 2
Engineering: Focused Hacker 2, Hacking Expert 2, Speedy Hacker 2, Alarm Expert 2, Vending Expert 2, Prolific Inventor
Combat: Photographer's Eye 2, Damage Research 2, Damage Research, Armored Shell 2, Armored Shell, Human Inferno 2
Upgraded Weapons: All if possible. If not then: Grenade launcher, Chemical thrower, Machine Gun, Shotgun
If you want to specialize in melee attacks then use the following:
Plasmids: Telekinesis, Sonic Boom, Winter Blast 3, Electro Bolt 2, Insect Swarm, Enrage
Physical: Bloodlust, SportBoost 2, Medical Expert 3, Hacker's Delight 2, Eve link 2, Eve Saver
Engineering: Focused Hacker 2, Hacking Expert 2, Speedy Hacker 2, Alarm Expert 2, Vending Expert 2, Safecracker 2
Combat: Armored Shell 2, Wrench Jockey 2, Wrench Jockey 1, Wrench Lurker 2, Damage Research 2, Static Discharge 2 (for the first few levels, then change it to Frozen Field)
Upgraded Weapons: Shotgun, Grenade Launcher and Machine Gun
If you want to specialize in stealthy game, then:
Plasmids: Telekinesis, Cyclone Trap, Target Dummy, Winter Blast 3, Incinerate 2, Enrage
Physical: Medical Expert 2, Eve Saver, Booze Hound, Hacker's Delight 3, Eve link 2, Natural Camouflage
Engineering: Focused Hacker 2, Prolific Inventor, Speedy Hacker 2, Alarm Expert 2, Clever Inventor, Shorten Alarms 2
Combat: Armored Shell 2, Photographer's Eye 2, Damage Research 2, Wrench Lurker 2, Human Inferno 2, Machine Buster 2
Upgraded Weapons: Crossbow and Grenade launcher
The Rosies are a pain in the @@@, the rivet gun can kill you in 2 or 3 shoots. So strategize
"LOL at the Big Daddies" strategy:
If you have: the chemical thrower fully upgraded, all the damage bonuses for the Big Daddies, and any of damage research tonics. Then just use your electric gel. One canister will deplete all of the health of an Elite Big daddy
Easy way to the defeat a Bouncer:
-Hack two Security Bots or be near a Security Camera
-Attach 3-5 proximity mines to an explosive tank, and then throw it to the Bouncer
-Retreat a couple of ft and let the bots do the job.
-Always move in circles or zigzag to avoid the Bouncer, especially when he charges towards you. If he hits you it will drain most of your health.
-As soon as he stunts you, shoot him with an electric buck (if he is at close proximity) or use your Electro bolt plasmid.
It stunt the bouncer and give you time to recover.
Easy way to defeat a Rosie (if you have the Hypnotize Big Daddy Plasmid):
-Find a Rosie and tag him with your Hypnotize Big Daddy Plasmid.
-Start a fight with another Rosie and let the two of them battle it out.
-Having friendly bots or turrets is a plus. Less work for you
Remember that the Hypnotize Big Daddy plasmid will drain your entire Eve bar when used, so try using it only when you have a low amount of eve.
CAUTION: Do not use the electric flesh tonic when you have a Big Daddy protecting you.
Way to defeat a Rosie:
-First of all: Make a perimeter. Place Trap bolts, hack turrets, hack cameras, hack bots, or anything that can be of aid. Do not fight the Rosie in too tight spots or in places too open.
-Have 9/9 health packs.
-Attach 3-5 proximity mines to an explosive tank, and then throw it to the Rosie.
-Use your armor piercing bullets and Electric buck
-Once you have depleted at least 2 quarters of the Rosie’s health. Use the electric gel to finish him off.
When fighting Atlas:
-Have a the medical expert 3&2 and the eve saver physical tonics
-Upgrade the health and eve bar at least twice
-Fully Upgrade the chemical thrower, machine gun, and the shotgun
-Have 9 health packs
-Have 200/200 electro gel
In the first round: Use the electric buck ammo and the antipersonnel machine gun ammo.
In the second round: Use the electro gel (he will remain immobile) and ignore the security bots. (Remember to use your health packs)
In the 3rd and final round: Use the electro gel once again (Don’t forget to use your medpacks).