DEFINITELY get Alchemy. If poisons have even half the capacity for damage as they did in Oblivion, Bows will be your bread and poisons will be your butter. Plus it never hurts being able to craft Invisibility potions for when you get caught. Or Night-Eye
for exploring caves. Possibilities are endless.
Remember that skills now come with perks that give skills more general affects. Pickpocketing, for example, can be made to increase carrying weight or place poisons in people's pockets to kill them. While lockpicking increases
the chance of finding money or special treasure in chests.
These are things that weren't in Oblivion and I think I'm going to love it.