Mine has the Digital TV tuner attached so whether I'm gaming or my kids are watching tv/Netflix my Xboxone is on a lot. Been in instant on mode since day one 2013 and still going strong. It will be fine.
I tend to fall asleep watching youtube and Netflix.. the 1 hour 6 hour inactivity power off does not work with those apps so my XB has basically been on and I mean powered on for probably 80% of the time I have owned it (day 1er) and I have had no issues
what so ever