So here is my problem. I've notice recently that it takes a bit of effort to get the wireless controller to turn on or hook up with the xbox once its powered up. It'll act like its not paired up and then after a few more guide button presses it'll connect. I didn't think much of it then.Then I fired up Rock Band 3 and noticed that the Lips mics were very scratchy and sounded bad, like a bad connection, even after I replaced batteries and re-synced it (replaced batteries in the controller too) . After I plugged in a wired mic all was fine.
My only conclusion is that the wireless connection of the peripherals is poor. I have an unobstructed 5 feet of distant between me and the console.