After you'd upgraded the hard-drive & then did the clean install of Vista SP1, you
should have (a) uninstalled the Norton free-trialware AND THEN (b) downloaded/run the Norton Removal Tool (c) BEFORE you installed the McAfee application AND BEFORE you installed
any updates (including IE upgrades).
Since you didn't, there's a very good chance that the McAfee application never installed or has ever worked properly since 09 February 2012 (no matter how many times you uninstalled/reinstalled it).
OPTION A: Free unlimited installation and compatibility support remains available (at least for now) for issues related to Windows Vista Service Packs. Availability of chat or e-mail support differs depending on your geographic
location. Some issues may require more advanced support for which there is a charge:
OPTION B (Recommended): You may be seeing the effects of a longstanding & ongoing hijackware infection, possibly compounded by a rootkit (or bootkit) infection. See...
Repost: The computer should NOT be connected to the internet or any local networks (i.e., other computers) in its current state. All of your personal data (e.g., online banking & credit-card passwords) should be considered at-risk, if not
Wish I'd had better news for you. Good luck!
-- ~Robear Dyer (PA Bear) Microsoft MVP (Windows Client) since October 2002