1) Was it working fine before?
2) Do you recall making any changes to the computer prior to this issue?
3) Is this issue confined only to ITunes?
4) Do you have sound on your computer?
Method 1: Run the fixit available in the link below and check if that makes any difference
Diagnose and repair sound playback problems automatically
Method 2: You follow the steps mentioned in the Apple’s link below which addresses similar issue
"ITunes cannot run because it has detected a problem with your audio configuration"
If the issue still persists, you may want to post your query on Apple Discussion Forum or contact their support for any known issues
Thanks and Regards
Microsoft Answers Support Engineer
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