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Have you tried right-clicking on the shortcut to the program, or the .exe, and selecting the "Run As Administrator" option? Do so even if your user is an Admin.
Try right-clicking on the actual Setup.exe and selecting the "Run As Administrator" option? Do so even if your user is an Admin.
Try this Forum too.
Official eMule-Board
http://forum.emule-project.net/index.php?act=idx&s=224dd664473ee954ba596a9f3a3141bd