1. When do you get this error message?
2. Are you getting this error while using any particular program? (Specify the program)
3. Have you made any changes to the computer prior to this issue?
I would suggest you to run the fixit from the following Microsoft Fixit article and check if it helps.
Fix problems with programs that can't be installed or uninstalled:
If you are facing this issue while using Microsoft Office program, then I would suggest you to refer to the following Microsoft article and check if it helps.
"Error applying transforms. Verify that the specified transform paths are valid" error message when you run the Office 2000 Setup program:
Please provide us more information, so that we could help you fix the issue.
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