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Registry cleaners are unsafe. They can damage your system, make your computer unbootable, and stop your programs from running. They use all kinds of "algorithms" to see what items in your registry should be deleted, and then delete vital registry keys and values that are essential for your computer to run properly. There is no significant improvement in your computer performance from using them. They are the snake oil of the software market. See http://chris.pirillo.com/are-registry-cleaners-safe-to-use/