hi Wyatt. I'm Greg, 10 years awarded Windows MVP, specializing in Installation, Performance, Troubleshooting and Activation, here to help you.
One of these fixes usually works for the error:
https://www.thewindowsclub.com/windows-cannot-l...
(Avoid ad links which intrude into editorial copy, especially avoid Restoro, PC Repair Tool and Reimage ads)
https://blog.darrenjrobinson.com/recovering-fro...
https://www.whatech.com/computer-support/blog/6...
https://appuals.com/fix-windows-cannot-load-the...
https://appuals.com/fix-windows-cannot-load-the...
(Avoid ad links which intrude into editorial copy, especially avoid Restoro, PC Repair Tool and Reimage ads)
If none of those help then I'll give you all possible fixes for External Drive not detected. Even if you've tried one please try it again in sequence and report back results. I'll be standing by to help you here:
Disable any 3rd party antivirus, or uninstall and turn on built-in Defender, to see if that resolves it.
Right click Start button to open Disk Management, scroll down to try to find the drive on the map by size and label, right click on it to assign a drive letter so it's detected in File Explorer.
Try disabling or removing any 3rd party antivirus. I would run built-in Defender which always offers best Windows performance with least issues, and is from Microsoft who knows how to protect their OS best.
For USB drive not detected issue, first try steps here: https://mspoweruser.com/solved-usb-device-not-r...
Go into Device Manager to look for the drive under Disk Drives. It may be listed by it's model or Serial which you can google to determine which is it. Click on the Device, then Driver tab, choose Roll Back if available. If not then choose Uninstall, restart PC to reinstall driver. If that fails choose Update Driver, first Automatically, then if that fails choose Browse > Let Me Pick to try all previous drivers.
If no newer or this doesn't help, then go to the USB category in Device Manager, open each Enhanced, Hub and Host controller, from Driver tab select Roll back if available, or if not choose Uninstall.
If your keyboard and mouse are USB, first program the power button to effect the needed restart after Rolling back or uninstalling the driver. Go to Settings > System > Power & Sleep > Additional Power Settings > Choose what Power buttons do to choose Shutdown.
Test the drive using diagnostics to know for sure it's condition: https://www.lifewire.com/free-hard-drive-testin...
Follow this up with a DIsk Check from the Command Prompt if necessary: https://www.groovypost.com/howto/check-hard-dri...
You can check which Updates were installed just before this happened, then uninstall them at Settings > Update & Security > Windows Update > Installed Update History - look first for installed drivers. Then you can hide these Updates using the Hide Updates tool: https://www.tenforums.com/tutorials/8280-hide-s...
You can also try to System Restore to a point before this happened, then check for Updates using the Hide Updates Tool to block the Updates offered:
Check if the drive is detected in another PC. If so back up the data to a folder on it's desktop. Once you confirm all the data is off the external, wipe it with Diskpart Clean Command:
https://www.tenforums.com/tutorials/85819-erase...
If nothing else works see if you can run Data Recover on it using
Recuva: http://www.piriform.com/recuva/features
Then plug it back into the PC which cannot detect it, reformat in Disk Management:
http://www.wikihow.com/Format-an-External-Hard-...
If nothing works you can try file Recovery starting with Recuva: http://www.piriform.com/recuva/features
Feel free to ask back any questions. Based on the results you post back I may have other suggestions if necessary.
______________________________________________
Standard Disclaimer: There are links to non-Microsoft websites. The pages appear to be providing accurate, safe information. Watch out for ads on the sites that may advertise products frequently classified as a PUP (Potentially Unwanted Products). Thoroughly research any product advertised on the sites before you decide to download and install it.