Sure am having issues with these last few CU's. I keep a base Retail vm updated with CU dl from MS Update Catalog as this vm is kept offline for testing Insider builds from offline state, checking the sign-in of these builds.
After installing KB4487044, it disabled Windows Defender leaving it with the Red X, and not possible to scan. This was never an issue prior with any CU installed on Retail 17763. Putting it back online, updating and back working.
Last month, KB4476976 was not compatible with Norton Security, totally disabled Edge. Could not use the browser till I removed Norton. Later on in the week, will try Norton to see if the issue still persists with the latest CU.