Hi Steve,
Welcome to Microsoft Community.
I appreciate your interest in windows 10 and also for trying the troubleshooting steps to fix the issue. I understand the inconvenience you faced. I will help you with this.
I need more information about this issue so that I can assist you better.
1. What is the make and model of your computer?
2. What is the make and model of mouse ?
3. Are you using Wired or wireless mouse?
4. Which fix did you try?
5. What happens, when you try to use mouse ?
Method 1. Try to run hardware and device troubleshooter .
Follow the below steps.
1. Press the windows + X key then click on the Control panel.
2. Search for troubleshooting then click on hardware and device.
3. Under hardware and device click Configure a device.
4. Follow the on screen instructions.
Method 2. Try to install latest chipset drivers from manufacturer site and then check.
Hope this helps. If the issue remains unresolved, please get back to us and we would be happy to help.
Thanks.