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Running Vista Home Premium 64-bit, version 6.0.6002.18005, whenever I try to run Disk Cleanup I get the message "Disk Cleanup cannot clean up drive X:\.". This happens regardless of drive chosen (C, D (factory image partition), or F (attached backup drive)),
and regardless of whether I am running it for my files only or those of all users. It also happens when I boot up in safe mode.
C: drive has 314 GB of 687 GB free. It has NTFS file system.
First, verify that the time, date/year & time-zone are set correctly
Clear up your Temp File/Cache. Clean up the system (clearing out all the temp/tmp folders, and included all offline content, clearing the browser tif, delete cookies, etc. etc..