HI Sammy. I'm Greg, 10 years awarded Windows MVP, here to help you.
You will have to try it to see how they play together. If not and you want to keep Core Isolation you can use built-in Defender which always offers best Windows performance with least issues, and is from Microsoft who knows how to protect their OS best.
Here's how to enable Core Isolation:
https://www.elevenforum.com/t/enable-or-disable...
The great thing about MVP Shawn Brink's Ten Forums tutorials is that he is usually the best expert on the subjects he writes about, and is usually easily accessible in the Comments section of his tutorials where you can contact him if you need further help.
Troubleshoot Core Isolation Memory Integrity issues here:
https://allthings.how/how-to-fix-incompatible-d...
https://www.thewindowsclub.com/core-isolation-a...
https://www.kapilarya.com/fix-memory-integrity-...
https://support.microsoft.com/en-us/windows/why...
https://www.thewindowsclub.com/memory-integrity... (Avoid ad links which intrude into editorial copy, especially avoid Restoro, PC Repair Tool and Reimage ads)
https://allthings.how/how-to-fix-incompatible-d...
Feel free to ask back any questions. Based on the results you post back I may have other suggestions if necessary.
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