Have you sought assistance from your antimalware provider (Avast, AVG, Avira, McAfee, Norton, Trend Micro, etc)?
Alternatively, try these “free” on demand scanners which will not interfere with your resident AV program - you might need to run them in Safe Mode or Safe Mode With Networking:
Go to www.malwarebytes.org and download, install, update and run the free version – just follow the prompts. You may need to rename the installation file to 123.exe or something similar
to prevent the malware from disabling/blocking the installation. Or you might want to download the installation file to a flash drive or CD and then install Malwarebytes on the infected computer.
You may need to use one or more of the following offline scanners - you'll need to burn a CD using a different computer and change the boot sequence on your computer to run the scan - instructions are included with the links: