Try running Excel with the /regserver switch. With Excel closed, go to the Windows Menu and choose Run. There, enter the following, including the quotes:
"C:\Program Files (x86)\Microsoft Office\Office14\Excel.exe" /regserver
Of course, your path the Excel.exe may be different. This will start Excel and cause it to rewrite its registry keys and file association and the other plumbing that makes Excel work.
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