Outlook 2016 Will Not Open error: Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened

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I've upgraded to WIN 10 and also upgraded to Office 365/2016.

Outlook 2016 will not open with this configuration.

Error message: "Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened".

I also cannot start Outlook in safe mode to check add-ons from previous version 365/213.

I note from reading various posts that sometimes Evernote can cause issues, but have also not had problem with Evernote and Office 365/2013.

Appreciate any advice that may be available to resolve the issue.

[Original Title: Outlook 2016 Will Not Open]


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Answer
Answer

THIS WORKED!  However I did it slightly different:

1. Right click the Windows button, select Control Panel

2. Select Mail (Microsoft Outlook 2016) (32-bit)

3. Click Show Profiles

4. Remove the existing Profile (ALL PROFILES!)

5. Close Window

6. Start Outlook

7. Create a new Profile

CHEERS!

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Answer
Answer

Hi Neil,

Thank you for posting your query in Microsoft Office Community.

Refer to the following article and check if it helps.

I can’t start Microsoft Outlook 2010 or 2013 or receive the error “Cannot start Microsoft Office Outlook. Cannot open the Outlook Window” 

 https://support.office.com/en-us/article/I-can-t-start-Microsoft-Outlook-2010-or-2013-or-receive-the-error-Cannot-start-Microsoft-Office-Outlook-Cannot-open-the-Outlook-Window-d1f69da6-b333-4650-97bf-4d77bd7abb85?CTT=1&CorrelationId=20910bad-e0d8-4bcd-aa2a-a0859c222018&ui=en-US&rs=en-US&ad=US

Note: Also applicable to Office 2016.

Hope the above information helps. Reply if you need more assistance and I'll be happy to help you.

Thank you.

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Last updated September 14, 2021 Views 693,208 Applies to: