Cannot start microsoft outlook 2010 Error Message: "Cannot start Microsoft Outlook."

Follow the steps below and check if it helps:

1.       Reboot into Safe Mode. Do this by holding the F8 key down while the machine restarts.

2.       Open the Run dialog by using the Windows-R keystroke combination.

3.       Type “C:\Program Files (x86)\Microsoft Office\Office14\MLCFG32.CPL” (without the quotes). It is worth noting that I had to try both Program Files and Program Files (x86) to find the MLCFG32.CPL file.

4.       In the resulting Mail control panel applet, look to see where your PST file is located.

5.       Reboot to leave Safe Mode

6.       Make a copy of the corrupted PST file, this is critical if you are using POP3 to get your mail. The PST locates your mail on your machine. If you delete this file you’ll lose all your mail.

7.       Delete the corrupted PST file.

8.       Start Outlook and when prompted, create a new profile. If you are using IMAP your account information should be there and your mail should start working again. If you are using POP you’ll have to import mail from the old profile that you copied in step 6.