Try to open Excel in safe mode. If you can open Excel fine in safe mode, then disable the Add-ins in Excel.
Follow the steps to open Excel in safe mode.
Go to Start->click on all programs-> Accessories-> Run->
Type Excel /safe and click on ok (Note: there should be a space between excel and /)
How to disable Add-ins in Excel 2010:-
Step1: Click the File Tab in Excel 2010 and Click Excel Options.
Step2: In the left hand side of the Excel Options dialog box, click Add-Ins.
Step3: Under ‘Manage’ Click the COM Add-ins
Step4: Uncheck all the Add-Ins listed under COM Add-ins.
Step5: Click close and restart Excel.
Also refer the link and try to empty the clipboard and check if it helps.
Note: The thread link refers to Excel 2007, but the same can be used for Excel 2010 as well.
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