2011: Does not install, also not in compatibility mode for Win-7 or Win-XP. Installer denies installation right at the beginning.
2014: Works fine, no compatibility mode necessary.
2015: Works just as fine. They have given this version an overhaul of the whole GUI and it is now much easier to use and somewhat "app-like". I like it. It shrinks down my 27 GB C-partition to a mere 7.8 GB.
I tested on a core-i5 PC (motherboard: Asus H87 Pro) with Win-10 build 9879 (64 bit).
The result is nice because Acronis drills deep into the OS and works quite close to the hardware. Not bad for an early beta! :-)