I use an ASUS Swift as my main monitor, running at 144hz in Windows 10. My secondary monitor is some old Samsung 1080p monitor capped at 60hz. If I set my main display to run at 144hz in Windows, the 60hz display goes nuts. If anything is dragged around the screen it flickers and artifacts until the item is still.
So I'm stuck using my 144hz monitor at 60hz in Windows to avoid the possible seizure. :P