There were many years when Microsoft's Antivirus and antimalware were insufficient to protect a computer running Windows. However, this is no longer the case, as Windows Security is now highly rated and in many cases better than others.
I feel that it is fine to run non-Microsoft antivirus when you are not running Insider builds, but that you cannot expect them to run without issues, while Microsoft is in the midst of changing the OS that they are meant to protect, in ways that they have
no way to anticipate.
If you need or want to test other antivirus products towards the end of a build cycle, when the OS is almost ready for RTM, that makes sense, as I am sure that the antivirus vendors are also watching closely and testing throughout.
I have had no problems running Windows Security only for many years, but I am also more aware than some of potentially unsafe activities that might expose my computers to harm. On occasion, if I suspect something might have compromised my
computer, I will run other things, briefly, to scan and check for issues that might have been missed. Usually the only other one I try is MalwareBytes.
However, the history of the Windows Insider Program shows that using other antivirus/antimalware products on Insider builds (especially during a build upgrade) is a common source of problems reported here in these Forums. That is unlikely to change.