1. Are you talking about MSN Messenger or MSN webpage?
2. What is the exact error message that you when you open MSN messenger?
Click on the link mentioned below for information on how to troubleshoot error messages in MSN messenger:
If you are getting an error message when you open MSN webpage, then optimize Internet Explorer and check if it fixes the problem.
Refer this KB article for help:
Afzal Taher-Microsoft Support.
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