Thanks for posting your query to Microsoft forum. I will certainly help you with this.
I would suggest you to follow the methods below and check it helps.
Method 1: Run the Internet Explorer Troubleshooter.
The Internet Explorer Performance Troubleshooter is an automated tool which will check for any performance issues which are common with the Internet Explorer on the computer and provides the details on how to fix them. Follow these steps and
run the troubleshooter.
a) Press “Windows Logo” + “W” keys from the keyboard.
b) Type “Troubleshooting” in the search bar and press “Enter”.
c) In the “Troubleshooting” window, click on “View All” on the left pane.
d) Click on “Internet Explorer Performance”.
e) Click on “Advanced” and then click on “Run as Administrator”.
d) Click “Next” and follow the on-screen instructions to complete the troubleshooting process.
This is a common symptom of a registry protector. Try booting in safe mode and make your change there. Test your change there and reboot in safe mode to be sure that it is persisting across a boot. Then chances are that your registry protector will be
helping to make your preference persist (until the next time you want to change it.)