Hi
also read the other parts of Disk Cleanup
see if this program helps you to ascertain what is taking up the space:
http://www.jam-software.com/treesize_personal/
system restore by default will take up to 15% of the hard drive capacity
you may like to diminish that amount
http://www.vistax64.com/tutorials/76227-system-restore-disk-space.html
http://www.vista4beginners.com/System-Restore-Space-Used
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Disk Cleanup:
Delete files using Disk Cleanup
http://windows.microsoft.com/en-US/windows-vista/Delete-files-using-Disk-Cleanup
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Open Disk Cleanup by clicking the Start button , clicking
All Programs, clicking Accessories, clicking System Tools, and then clicking
Disk Cleanup.
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In the Disk Cleanup Options dialog box, choose whether you want to clean up your own files only or all of the files on the computer.
If you are prompted for an administrator password or confirmation, type the password or provide
confirmation.
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If the Disk Cleanup: Drive Selection dialog box appears, select the hard disk drive that you want to clean up, and then click
OK.
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Click the Disk Cleanup tab, and then select the check boxes for the files you want to delete.
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When you finish selecting the files you want to delete, click OK, and then click
Delete files to confirm the operation. Disk Cleanup proceeds to remove all unnecessary files from your computer.
The More Options tab is available when you choose to clean files from all users on the computer. This tab includes two additional ways to free even more disk space:
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Programs and Features. Opens Programs and Features in Control Panel, where you can uninstall programs that you no longer use. The Size column in Programs and Features shows how much disk space each program uses.
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System Restore and Shadow Copies. Prompts you to delete all but the most recent restore point on the disk.
System Restore uses restore points to return your system files to an earlier point in time. If your computer is running normally, you can save disk space by deleting the earlier restore points.
In some editions of Windows Vista, restore points can include previous versions of files, known as shadow copies, and backup images created with
Windows Complete PC Backup. This information will also be deleted. For more information about System Restore, search
Windows Help and Support for "system restore.
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also scan for malware
download update and scan with the free version of malwarebytes anti-malware
http://www.malwarebytes.org/mbam.php
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and read this microsoft information on optimizing windows
http://windows.microsoft.com/en-US/windows-vista/Optimize-Windows-Vista-for-better-performance