On startup A box pops up and says Asus setup and in the box it says C:\users\Don\AppData\Local\Temp\ 132218 Log.iniis lost

I have dealt with a large number of installations that displayed this behaviour: Some irritating error message or some severe malfunction while in Normal Mode, perfect operation while in Safe Mode. In each and every case the culprit was a startup task or some rogue service. Yours is the odd one out. I can see these options for you:
a) See if System Restore will fix it, or
b) Wait for some other respondent to offer a solution, or
c) Live with the irritation, or
d) Restore the machine to factory condition.

I saw this on another website... this works perfectly!

When booting I get error message under "asus setup" 105814 Log.iniis Lost?

Hi, you probably ran Ccleaner or similar and deleted this log file from your temporary folder, that is in use by a scheduled task. Open Task scheduler and expand the" task scheduler library". Open Asus and select the " i-setup" task , delete it, and you are done.